<img src="//bat.bing.com/action/0?ti=5599429&amp;Ver=2" height="0" width="0" style="display:none; visibility: hidden;">
Schedule Consultation
Blog Feature
Lisa Rosenthal

By: Lisa Rosenthal on March 10th, 2014

Print/Save as PDF

Update On CCS IVF - Comprehensive Chromosomal Screening

PGD | CCS - Comprehensive Chromosomal Screening | Fertility Treatment

CCS IVF: Prize Winning Fertility Treatment Update

Three years ago, Reproductive Medicine Associates of Connecticut (RMACT) had news to share with the world and we sent out the press release below, which you can read in its entirety. Since then, CCS has been a scientific technique that has been used successfully by our patients when it’s medically appropriate. Successful as defined by pregnancy and also as defined by babies born. One of the most common reasons for using CCS is for repeated miscarriages of seemingly healthy pregnancies. It’s probably not necessary to say how heartbreaking that is for men and women who are hoping to have a baby. CCS also gives peace of mind when there have been repeat losses, that with CCS, the possibility is much, much lower. Without a doubt, CCS has changed the lives of many men and women who have been trying to become pregnant and to deliver a baby.

Three years later, CCS continues to make significant differences in the lives of our patients.

~Lisa Rosenthal



RMACT recently participated in a breakthrough study titled "A Prospective Randomized Controlled Trial Demonstrating Significantly Increased Clinical Pregnancy Rates Following 24-Chromosome Aneuploidy Screening: Biopsy and Analysis on Day 5 with Fresh Transfer," which was led by Infertility Specialist Richard Scott, M.D. and Nathan Treff, Ph.D., of Reproductive Medicine Associates of New Jersey (RMANJ), an affiliate of RMACT.  

Pre-Implantation Genetic Screening (PGS)

This study, which earned the top research award from the American Society for Reproductive Medicine (ASRM) in October 2010, examined technology that is the first and only fully validated system to reliably evaluate all chromosomes in a small biopsy obtained from an embryo during in vitro development. This is the first and only prospectively randomized trial showing real benefit from Pre-Implantation Genetic Screening (PGS) and RMACT is the only fertility practice in New England to offer it. 

“This technology will revolutionize reproductive medicine,” said infertility doctor Mark Leondires, M.D., Medical Director of RMACT and Lead Physician for RMACT on the Clinical Study. “The purpose is to identify the best embryos for a healthy pregnancy.  By selecting chromosomally normal embryos without damaging them, pregnancy rates were dramatically increased to more than 90 percent and miscarriage rates were lower compared to the control group. This data is historic in its nature and implications.”

Sustained implantation rates were 75 percent in the study group, much higher than compared to 56 percent in the control group.  Clinical pregnancies, which are a typical result of genetic abnormalities, were significantly lower in the study group (60 percent) than versus the control group (92 percent).

“Our goal is one embryo, one healthy baby," said Dr. Scott.  "So, the driving force behind most of our research is to assess reproductive competency to better predict which embryo will most likely produce one healthy baby.  This is the first study of its kind that has shown dramatically improved clinical pregnancy rates with blastocyst biopsy, 24 Chromosome Aneuploidy Screening and fresh embryo transfer.  Though similar screening technologies are being marketed, none have been validated through the critical studies, culminating with a randomized clinical trial, which provides this high level of medical evidence.”  


The procedure starts when a couple goes through In Vitro Fertilization (IVF) Treatment with intracytoplasmic sperm injection (ICSI); the embryo is then grown to the blastocyst stage and a small biopsy of five to 10 cells is taken from the embryo on day five to six days of life. The biopsy sample then goes through computer analysis to identify any abnormalities among the chromosomes.  This process identifies chromosomal disorders such as Down syndrome before the embryo is transferred into the female patient’s uterus. This error rate of the technology is less than one percent in more than 4,000 embryos tested.


About Comprehensive Chromosomal Screening


What separates this technique of Comprehensive Chromosomal Screening (CCS) from other PGS processes is that the embryo is able to grow for five or six days, allowing the cells to split and the chromosomal analysis to be more accurate.  In addition, since the technology can be used to find small breaks in chromosomes and even single gene disorders it defines itself as the most robust and reliable technology for evaluating pre-conception embryos available.  RMANJ has previously shown 24 chromosome analysis technology to be significantly more reliable than other existing methods.  However, with this latest clinical study, the new technology has been improved because it no longer requires freezing embryos for weeks before thaw and use.  The breakthrough is based on a shorter timeline, which has better results; the same comprehensive screening is conducted within hours instead of days.  It is the first technology of its kind that allows for assessment of blastocysts and still enables a fresh embryo transfer, which generally has a higher success rate than freezing embryos.

The study included patients seeking IVF who were less than 43 years old and had no more than one prior failed IVF cycle.  The control group underwent routine care and typical screening methods, whereas the study group underwent biopsy of the blastocyst and CCS on day five. 
In a related retrospective evaluation presented with this research, the study shows that this new technology dramatically decreases the occurrence of abnormal pregnancies such as Down or Turner syndromes.  This technology will allow women in their late thirties and forties, who normally have a high risk for genetic abnormalities, to nearly eliminate these risks and thereby maximize their chances for a successful pregnancy with in-vitro fertilization.  CCS represents a major step forward in helping patients have healthy pregnancies and thereby allowing them to choose a single embryo transfer to minimize the risk of twins. 

“A singleton pregnancy is the safest for mother and baby,” stated Leondires.  “This technology will allow couples to choose a single embryo transfer without jeopardizing their chance for success.  It is truly an amazing advance which will change the landscape of reproductive medicine in the future for both patient and physicians.”  

Infertility affects 7.3 million Americans and for 20 percent of infertility patients the cause is unknown, according to The National Infertility Association.  Through 24 chromosome aneuploidy screening, fertility doctors can determine which embryos are normal, increase healthy pregnancies while at the same time reduce the number of miscarriages.  The technology will transform reproductive medicine and instill confidence in transferring only one embryo, leading to fewer multiple gestations. In addition, for patients who have had several miscarriages, it can enable them to make informed decisions about their next steps, such as working with an egg donor. 


Follow Lisa on Google+



About Lisa Rosenthal

Lisa has over thirty years of experience in the fertility field. After her personal infertility journey, she felt dissatisfied with the lack of comprehensive services available to support her. She was determined to help others undergoing fertility treatment. Lisa has been with RMACT for eleven years and serves as Patient Advocate and the Strategic Content Lead.

Lisa is the teacher and founder of Fertile Yoga, a program designed to support men and women on their quest for their families through gentle movement and meditation.

Lisa’s true passion is supporting patients getting into treatment, being able to stay in treatment and staying whole and complete throughout the process. Lisa is also a Certified Grief Recovery Specialist, which is helpful in her work with fertility patients.

Her experience also includes working with RESOLVE: The National Infertility Association and The American Fertility Association (now Path2Parenthood), where she was Educational Coordinator, Conference Director and Assistant Executive Director.